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. 2021 Apr 22;22(9):4404. doi: 10.3390/ijms22094404

Figure 1.

Figure 1

Cell viability of nanostructured microemulsions systems (NaMESys) in Statens Seruminstitut Rabbit Cornea (SIRC) cells by Short Time Repeated Exposure (S.T.R.E.) protocol. SIRC were repeatedly exposed 6 times at 1.5 h intervals between each repeated exposure for 5 min with or without wash to negative control (CTRL−), 0.01% BAK positive control (CTRL+), undiluted test items (100%) and to different dilutions of the same test items corresponding to 20%, 10%, 5% and 2.5% concentrations of (A) control formulation (NaMESys) or (B) microemulsion carrying sorafenib tosylate 0.3% (NaMESys-SOR). A dotted line placed at 50% represents the cut-off value to determine cytotoxicity potential according to ECVAM protocol DB-ALM n° 17. Data are presented as mean ± S.E.M. of two independent experiments performed in triplicate. ** p ≤ 0.01, *** p ≤ 0.001 and **** p ≤ 0.0001 vs. cut-off at 50%.