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. 2021 Apr 22;22(9):4404. doi: 10.3390/ijms22094404

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Nanostructured microemulsions system carrying 0.3% sorafenib (NaMESys-SOR) inhibited laser-induced choroidal neovascularization (CNV) when delivered by topical administration. CNV volumes were measured after 7 days from laser-induced damage by Isolectin B4 staining of retinal pigment epithelium (RPE)-choroid flat mounts. n = 5 mice per group. The following number of spots were analyzed: NaMESys = 14, NaMESys-SOR = 20. Data are presented as the mean ± SEM. * p = 0.0135 vs. vehicle (NaMESys). On the right, representative pictures of CNV. Scale bar: 100 µm.