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Problem, Intervention, Comparison, Outcome (PICO) strategy.
| Parameter | In Vitro Studies | Clinical/In Situ Studies |
|---|---|---|
| P (Population) | Primary teeth / dentin discs | Children in need of a restoration |
| I (Intervention) | Restoration with prior application of a cavity disinfectant | |
| C (Comparison) | Conventional restoration | |
| O (Outcome) | Effect of cavity disinfection on dentin bond strength | Effect of cavity disinfection on clinical success |
