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ELISA analysis of caspase-3 and caspase-8 activation as markers for apoptosis. Protein levels of caspase-8 and caspase-3 (pg/mL) in BJ + SK-MEL-28 co-culture cells treated with T + C therapeutic combination for 72 h. *** p < 0.001, **** p < 0.0001 vs. control or untreated cells and **** p < 0.0001 vs. trametinib group. Each bar represents mean ± standard deviation (n = 3).
