C	celecoxib
T	trametinib
T + C	celecoxib + trametinib
NF-κB	nuclear factor-kappa B
p NF-κB	phosphorylated nuclear factor-kappa B
PI3K	phosphatidylinositol 3-kinase
mTOR	mechanistic target of rapamycin
panAKT	protein kinase B
pan pAKT	phosphorylated protein kinase B
IKK	IkB kinase
MAPK	mitogen activated protein kinase
STAT3	signal transducer and activator of transcription 3
PTEN	phosphatase and tensin homolog
MITF	microphthalmia transcription factor
COX-2	cyclooxygenase-2
PGE2	prostaglandin E2
VEGF	vascular endothelial growth factor
HIF-1α	hypoxia inducible factor–1 alpha
TGF- β	transforming growth factor beta
LDH	lactate dehydrogenase
GAPDH	glyceraldehyde 3-phosphate dehydrogenase
PD-1/PD-L1	programmed ccell death–1/programmed cell death-ligand 1
TAM	TAM receptor protein tyrosine kinases (TYRO3, AXL, MER)
α-MSH	alpha-melanocyte stimulating hormone
CAFs	cancer-associated fibroblasts
FSP-1	fibroblast specific protein 1
FAP-α	fibroblast activation protein-alpha
α-SMA	α-smooth muscle actin
PDGFR	platelet-derived growth factor receptor
YAP/PAX 3	yes-associated protein 65/paired box gene 3
TEAD/SMAD	transcriptional enhancer factor TEF-1 domain family member 1
SIRT1	family of proteins that are the main signal transducers for the receptors of the TGF-β