Figure 3.

Mutation spectrum in GB. (A) Percentage of variant classification, plotted as a percentage of the total number of variants detected. (B) Percentage of mutation type, plotted as a percentage of the total number of variants detected. (C) Percentage of single-nucleotide variant (SNV) classification, plotted as a percentage of the total number of SNVs detected. (D) Oncoplot of the distribution of mutations found in our samples in the most frequently mutated genes in GB. Each column represents one sample (9 regions per tumor) and each row a different gene. Colored squares show mutated genes, while empty (gray) squares show no mutated genes. The different types of mutations are colored according to the type of variant: orange, splice site mutation; blue, frameshift deletion; green, missense mutation; red, nonsense mutation; and black, multi-hit mutation. Genes annotated as “multi-hit” have more than one type of mutation in the same region. The bar graph on the right shows the total number and percentage of mutated regions for each gene, out of the total 27 regions, colored according to mutation type. The upper graph shows the total number and type (different color) of mutations for each tumor region.