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. 2021 Apr 23;10(9):1834. doi: 10.3390/jcm10091834

Table 2.

Overview of literature search.

Case nr. Organs/Tissue Sites Age Sex Type LP–PCD Material within Histiocytes (ISH) Serum Immunofixation Ref.
Skin Bonemarrow Kidney GI-Tract Liver Abdomen unsp. Heart Thymus Breast Lung Spleen Head an Neck Lymph Node
1 71 M L MGUS NA IgG kappa [6]
2 57 M G LPL IgM/IgG/IgD kappa/lambda IgG kappa [7]
3 56 F L MM Kappa IgG kappa [8]
4 56 M L MALT lymphoma Kappa NA [9]
5 75 F G MM Kappa IgG kappa [10]
6 66 F L MM Kappa IgA kappa [11]
7 86 M L MZL Negative IgM
8 68 F L NA Kappa Kappa [12]
9 49 M G MM NA NA
10 74 F G DLBCL IgM kappa IgM kappa [13]
11 83 F L MM Kappa NA [14]
12 73 F G MGUS NA IgG kappa [15]
13 79 M L MM Negative NA [16]
14 71 M L LPL IgM Kappa IgM kappa [17]
15 67 M L MGUS IgG kappa IgG kappa
16 74 M L MM IgG kappa IgG kappa
17 65 M G None Negative IgG kappa [18]
18 72 F L MM Kappa Kappa [19]
19 36 M L None Kappa Negative [1]
20 63 M L B-cell lymphoma NA IgM Kappa [2]
21 40 M L MM Kappa Kappa
22 71 M G MM Kappa IgG kappa
23 65 F L MM Kappa IgA Kappa
24 70 M G MM NA IgG Kappa
25 73 M L MGUS NA IgG Kappa
26 56 M L MM NA IgG Kappa
27 60 M G MM Kappa IgG kappa [20]
28 48 M L MM Kappa Kappa [21]
29 70 M L MM NA IgG kappa [22]
30 36 F L MALT lymphoma Kappa IgG [23]
31 27 F L EMZL Lambda Lambda [24]
32 67 M L MGRS Kappa IgG kappa [25]
33 51 M G MM IgG/lambda/kappa IgG lambda [26]
34 75 M L MM IgG kappa IgG kappa
35 46 F L MM NA IgA kappa
36 74 M L LPL IgM IgM
37 63 M L LPL Lambda IgM lambda
38 79 M L LPL Kappa IgM kappa
39 43 M G EMZL IgA kappa Negative
40 63 F L EMZL IgM lambda NA
41 50 F L EMZL IgM lambda NA
42 33 F L EMZL Kappa NA
43 73 F L EMZL NA NA
44 58 M L EMZL NA NA
45 68 F L SMZL Lambda Negative
46 56 M L None NA Negative [27]
47 58 M L EMZL Kappa NA [28]
48 46 M L MM Lambda NA [29]
49 62 F L EMZL IgM NA [30]
50 80 F L LPL NA IgM kappa [31]
51 52 M L MM Negative IgG kappa
52 57 F L MM Kappa IgA kappa [32]
53 53 F G LPL NA IgM lambda [33]
54 69 M G MGUS NA Kappa [34]
55 NA M L None NA NA [35]
56 71 F L MALT lymphoma IgG kappa Negative [36]
57 43 F L MGUS Neg IgD kappa [37]
58 91 F G EMZL IgM/IgG/kappa IgM kappa [38]
59 77 M L MZL Kappa Negative [39]
60 53 M L MALT lymphoma NA NA [40]
61 38 F L MM IgA kappa IgA kappa [41]
62 30 F L None NA Negative [42]
63 54 F L MALT lymphoma Kappa NA [43]
64 72 F L BPDCN NA Negative [44]
65 32 M L EMZL NA NA [45]
66 55 F L None IgA/IgG/IgM/kappa/lambda Negative [46]
67 54 F L MGUS Kappa NA [47,48]
68 89 F L MZL Kappa NA
69 50 F L MZL Kappa NA
70 63 M L MM Kappa NA
71 68 M L MGUS IgG kappa IgG kappa
72 78 F L MGUS NA NA [49]
73 80 M L None NA Negative [50]
74 20 F L None Lambda NA [51]
75 62 F G MGUS NA IgG kappa [52]
76 64 M L EMZL NA NA [53]
77 57 F L EMZL NA NA
78 48 F G MGUS Kappa IgG kappa [54]
79 51 F L MGUS IgM/IgG NA [55]
80 38 M L None IgG/kappa/lambda Negative [56]
81 32 F L None Kappa NA [57]
82 50 F L LPL NA IgM kappa [58]
83 67 M L MM IgG IgG [59]
84 27 F L None NA NA [60]
85 54 F L EMZL Kappa NA [61]
86 75 F L MGUS NA IgG kappa [62]
87 63 M L MM NA IgG kappa [63]
88 53 F L MALT lymphoma Non-crystallized IgG kappa IgA kappa [5]
89 52 M L MGUS NA IgM kappa [64]
90 70 M L DLBCL NA IgM kappa
91 65 M L MGUS NA IgG kappa
92 64 M L MG Negative IgG kappa [65]
93 76 F L MZL IgM lambda IgM lambda [66]
94 66 M G MM NA IgG kappa [67]
95 66 M L MGUS Lambda IgG lambda [68]
96 65 M G None NA Kappa [69]
97 54 M L MM NA IgG kappa [70]
98 81 F L MALT lymphoma IgM kappa Negative [71]
99 56 F L None Kappa/lambda Negative [72]
100 52 M L MM Non-crystallized kappa NA [4]
101 41 M L MM NA IgD kappa [73]
102 62 F L MM Kappa IgG kappa [74]
103 70 F L None Kappa Kappa [75]
104 79 F L MM IgA kappa IgA kappa [76]
105 69 F L MALT lymphoma NA Negative [77]
106 49 M G MGUS Kappa IgG kappa [78]
107 72 F G MM Kappa IgA kappa
108 62 F L MM NA IgG kappa [79]
109 74 F L MM Negative IgA lambda [80]
110 51 M G MM IgG kappa Kappa [81]
111 59 M L EMZL IgG/IgM/kappa/lambda NA [82]
112 58 M L MZL Lambda IgM lambda [83]
113 73 M G MM IgA kappa IgA kappa [3]
114 62 F L EMZL Kappa Negative [84]
115 48 M L MM IgA kappa IgA kappa [85]
116 53 M L MM IgA kappa Negative
117 50 M G MM IgG kappa Negative
118 77 F L MM Kappa Negative
119 66 M L MGUS IgA kappa IgA kappa
120 66 M G LPL IgM kappa Negative
121 68 F L LPL IgM kappa IgM/IgG/kappa
122 53 F L LPL IgM kappa IgM kappa
123 70 M G LPL IgM kappa NA
124 70 M G LPL IgM lambda NA
125 35 F L LPL IgA kappa IgG lambda
126 54 F L None IgG lambda NA
127 72 F L LPL IgM kappa NA [86]
128 44 M G LPL IgG kappa IgG kappa [87]
129 73 F L None IgG/kappa/lambda IgG [88]
130 81 F L MALT lymphoma IgM lambda NA [89]
131 61 F L LPL IgM/IgG/kappa/lambda IgM kappa [90]
132 54 F L None IgA/IgM/IgG/kappa/lambda NA [91]
133 46 M L LPL Negative IgG/IgM/lambda [92]
134 49 M L B-cell lymphoma NA NA [93]
135 78 F G LPL Negative IgM kappa [94]
136 77 F G LPL IgM kappa NA
137 18 F L LPL Negative NA
138 75 M G MM IgG kappa NA [95]
139 60 M G MM IgA kappa NA [96]
140 75 F L MGUS Non-crystallized kappa IgG kappa Pres

The table demonstrates the cases of storing histiocytosis we identified by literature review. The cases are numbered, and the different organ systems affected are identified by different colors in the left columns. To the right, we present patient age, sex, associated disorders, material identified, and results of immunofixation. Abbreviations: LP–PCD—Lymphoproliferative–Plasma cell disorder; M—Male; F—Female; L—Localized; G—Generalized; ISH—In-situ hybridization; MGUS—Monoclonal gammopathy of undetermined significance; MGRS—Monoclonal gammopathy of renal significance; MM—Multiple myeloma; LPL—Lymphoplasmacytic lymphoma; DLBCL—Diffuse large B-cell lymphoma; BPDCN—Blastic plasmacytoid dendritic cell neoplasia; MALT lymphoma—Mucosa-associated lymphoid tissue lymphoma; EMZL—Extranodal marginal zone lymphoma; SMZL—Splenic marginal zone lymphoma; MZL—Marginal zone lymphoma; NA—Not available.