Aβ	amyloid-β peptide
AD	Alzheimer’s disease
ADME	absorption, distribution, metabolism, and excretion
AMPA	α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic a
BSA	bovine serum albumin
CNS	central nervous system
DiFMUP	6,8-difluoro-4-methylumbelliferyl phosphate
DMSO	dimethyl sulfoxide
DTT	dithiothreitol
ECFP	extended-connectivity FingerPrint
ERK	extracellular signal-regulated kinase
HTS	high-throughput screening
KIM	kinase-interaction motif
KO	knockout
LTD	long-term depression
LTP	long-term potentiation
MAPK	mitogen-activated protein kinase
Ni-NTA	nickel-nitrilotriacetic acid
NMDA	N-methyl-D-aspartate
PP1	protein phosphatase 1
PROTAC	proteolysis targeting chimeras
PSD	postsynaptic density
PTK	protein tyrosine kinase
PTP	protein tyrosine phosphatase
PTS	protein thermal shift
RT	room temperature
SAR	structure activity relationship
SD	standard deviation
SEM	standard error of the mean
STEP	striatal-enriched tyrosine phosphatase
TCEP	tris(2-carboxyethyl)phosphine
TKI	tyrosine kinase inhibitor
Tm	melting temperature