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Circulating blood components in patients with late stage non-small cell lung carcinoma. Several components can be isolated at diagnosis (baseline), including circulating free-DNA, circulating tumor cells, microRNA, platelets, and extracellular vesicles (mainly exosomes) for biomarker assessment. The majority of next-generation sequencing technologies are currently being developed from circulating free-DNA and from nucleic acids extracted from circulating tumor cells (green circles).
