Table 2.
Genes related to the “drug resistance” process modulated in the multidrug-resistant 82.3 cells compared to the sensitive MT-CHC01.
| Up-Regulated Genes | Average Fold Change | SD | Down-Regulated Genes | Average Fold Change | SD |
|---|---|---|---|---|---|
| AHR | 152.60 | 4.39 | ABCC1 | 0.11 | 0.04 |
| APC | 8.80 | 1.82 | ABCC2 | 0.04 | 0.01 |
| ARNT | 3.06 | 0.46 | ABCC3 | 0.33 | 0.08 |
| BCL2 | 2.22 | 0.49 | ABCC5 | 0.25 | 0.08 |
| BRCA2 | 11.43 | 1.41 | BAX | 0.46 | 0.07 |
| CCND1 | 1.67 | 0.44 | BCL2L1 | 0.09 | 0.03 |
| CDKN1A | 29.58 | 0.44 | CCNE1 | 0.26 | 0.03 |
| CYP2E1 | 6.37 | 1.99 | CDK2 | 0.41 | 0.07 |
| EGFR | 5.15 | 1.60 | CDK4 | 0.28 | 0.14 |
| EPHX1 | 1.69 | 0.51 | CDKN1B | 0.27 | 0.15 |
| HIF1A | 7.07 | 0.87 | CLPTM1L | 0.07 | 0.02 |
| MET | 3.16 | 0.40 | CYP3A5 | 0.11 | 0.03 |
| MSH2 | 5.66 | 1.25 | ELK1 | 0.01 | 0.01 |
| MYC | 1.74 | 0.19 | ERBB2 | 0.16 | 0.08 |
| NAT2 | 10.82 | 0.17 | GSK3A | 0.20 | 0.06 |
| PPARA | 2.19 | 0.31 | GSTP1 | 0.40 | 0.13 |
| PPARG | 9.29 | 1.41 | MVP | 0.15 | 0.07 |
| RB1 | 5.11 | 0.74 | NFKB2 | 0.22 | 0.00 |
| SOD1 | 1.69 | 0.17 | NFKBIB | 0.27 | 0.07 |
| TOP2A | 3.91 | 0.54 | RARA | 0.39 | 0.07 |
| TOP2B | 16.13 | 1.66 | RARG | 0.18 | 0.05 |
| TPMT | 6.25 | 0.01 | RELB | 0.36 | 0.08 |
| UGCG | 6.69 | 0.43 | RXRA | 0.18 | 0.04 |
| - | - | - | RXRB | 0.49 | 0.14 |
| - | - | - | SULT1E1 | 0.34 | 0.04 |
| - | - | - | TP53 | 0.07 | 0.02 |