Table 3.
Genes related to the “epithelial to mesenchymal transition” process modulated in the multidrug-resistant 82.3 cell line compared to the sensitive MT-CHC01.
| Up-Regulated Genes | Average Fold Change | SD | Down-Regulated Genes | Average Fold Change | SD |
|---|---|---|---|---|---|
| CALD1 | 3.51 | 0.12 | AKT1 | 0.17 | 0.03 |
| CAMK2N1 | 14.79 | 3.50 | BMP2 | 0.05 | 0.02 |
| CAV2 | 2.17 | 0.84 | ESR1 | 0.33 | 0.09 |
| CDH2 | 5.47 | 1.08 | F11R | 0.19 | 0.04 |
| COL5A2 | 3.62 | 1.07 | FOXC2 | 0.05 | 0.00 |
| DSC2 | 11.94 | 2.90 | IGFBP4 | 0.02 | 0.01 |
| DSP | 6.91 | 0.55 | ILK | 0.23 | 0.01 |
| EGFR | 5.92 | 0.59 | ITGA5 | 0.01 | 0.00 |
| FGFBP1 | 6.46 | 2.95 | KRT19 | 0.28 | 0.01 |
| FN1 | 31.61 | 6.18 | KRT7 | 0.37 | 0.13 |
| FZD7 | 2.10 | 0.41 | MAP1B | 0.13 | 0.01 |
| GSK3B | 5.43 | 0.34 | MSN | 0.15 | 0.04 |
| IL1RN | 4.31 | 0.50 | MST1R | 0.07 | 0.01 |
| ITGAV | 3.73 | 0.16 | NOTCH1 | 0.10 | 0.03 |
| ITGB1 | 4.55 | 0.29 | PPPDE2 | 0.36 | 0.00 |
| MMP9 | 29.40 | 0.13 | SPP1 | 0.16 | 0.01 |
| OCLN | 5.93 | 0.06 | - | - | - |
| PLEK2 | 2.19 | 0.29 | - | - | - |
| PTK2 | 2.02 | 0.51 | - | - | - |
| PTP4A1 | 2.89 | 0.03 | - | - | - |
| RAC1 | 13.17 | 1.75 | - | - | - |
| SIP1 | 2.58 | 0.35 | - | - | - |
| SMAD2 | 4.04 | 0.45 | - | - | - |
| STEAP1 | 2.78 | 0.47 | - | - | - |
| TCF4 | 6.10 | 0.26 | - | - | - |
| TGFB1 | 2.09 | 0.61 | - | - | - |
| TGFB2 | 89.35 | 16.11 | - | - | - |
| TGFB3 | 1.82 | 0.30 | - | - | - |
| TIMP1 | 1.67 | 0.14 | - | - | - |
| TMEFF1 | 12.51 | 4.12 | - | - | - |
| TSPAN13 | 5.72 | 0.59 | - | - | - |
| VCAN | 168.97 | 28.95 | - | - | - |
| VIM | 504.06 | 83.12 | - | - | - |
| VPS13A | 9.95 | 0.97 | - | - | - |