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. 2021 Apr 23;22(9):4439. doi: 10.3390/ijms22094439

Figure 4.

Figure 4

The AMPK inhibitor, compound C, attenuates the protective effects of metformin against NMDA-induced cell loss in the ganglion cell layer (GCL). The number of cells in the GCL and thickness of the inner plexiform layer (IPL) were measured seven days after intravitreal injection. (A): Vehicle (DMSO, (a); NMDA + vehicle (b); NMDA + metformin (c); NMDA + metformin + compound C (d). The doses of NMDA, metformin, and compound C were 200 nmol/eye, 20 nmol/eye, and 10 nmol/eye, respectively. Scale bar, 30 µm. (B): Bar graph showing the number of cells in the GCL and thickness of the IPL. n = 6. ** p < 0.01; Kruskal–Wallis test.