Table 1.

Clinical manifestations in mice.

	Normal Mice	Vehicle-Treated APS Mice	Crassolide 5 mg/kg-Treated APS Mice
aPTT (s)	19.3 ± 7.2 ***	91.3 ± 21.4	43.3 ± 23.6 *
Platelet count (1 × 103 c3lls)	673 ± 199 ***	312 ± 183	495 ± 136 *
Anti-β2GPI (O.D. 450 nm)	0.11 ± 0.21 ***	1.96 ± 0.71	0.65 ± 0.42 **
Fetal loss (%)	14 ± 6 *	46 ± 8	23 ± 4 *

The data are presented as the means ± standard deviation of triplicate assays from 6–8 mice/group. * p < 0.05, ** p < 0.01, *** p < 0.001, versus vehicle-treated APS mice, as determined by a one-way ANOVA with Tukey’s multiple comparison test. APS, antiphospholipid syndrome; aPTT, activated partial thromboplastin time; β2GPI, β2-glycoprotein I.