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. 2021 Apr 24;22(9):4450. doi: 10.3390/ijms22094450

Table 1.

Summary of protein complex and PPI databases.

DB Information Interaction type Organisms Size Website
Complexes CORUM 3.0 Manually curated from experimental data Direct (physical) interactions Human (67%)
Mouse (15%)
Rat (10%)
& other mammals		 4274 complexes based on 4473 genes
(including 22% of human protein coding genes)		 http://mips.helmholtz-muenchen.de/corum/ (accessed on 9 March 2021)
Complex Portal (accessed 9 March 2021) Manually curated from experimental data Direct (physical) interactions 26 organisms across all domains of life

  • Human: 985 complexes

  • Mouse: 740 complexes

  • Yeast: 607 complexes

  • E. coli: 321 complexes

  • Others

 http://www.ebi.ac.uk/complexportal (accessed on 9 March 2021)
huMap 2.0 Integration of over 15,000 mass spectrometry experiments Direct (physical) interactions
(and proximity interactions)		 Human 6969 complexes consisting of 57,178 unique interactions among 9,968 proteins http://humap2.proteincomplexes.org/ (accessed on 9 March 2021)
PPIs IntAct
(accessed 11 March 2021)		 Manually curated from experimental data Direct (physical) interactions Human (61%)
Yeast (12%)
Mouse (8%)
& other organisms across all domains of life		 1,130,596 interactions among 119,281 proteins http://www.ebi.ac.uk/intact (accessed on 9 March 2021)
BioGRID 4.3 Manually curated from experimental data Direct (physical) interactions and genetic interactions 70 species

  • Budding yeast: 755,000 PPIs

  • Fission yeast: 79,000 PPIs

  • Human: 670,000 PPIs

  • Worm: 29,000 PPIs

  • Fly: 78,000 PPIs

  • All other organisms: 300,000 PPIs

 https://thebiogrid.org/ (accessed on 9 March 2021)
BioPlex 3.0 Experimental Direct (physical) interactions Human 118,162 interactions among 14,586 proteins https://bioplex.hms.harvard.edu/ (accessed on 9 March 2021)
PrePPI Predicted Direct (physical) and indirect (functional) interactions Human PrePPI contains 1.35 million PPIs for ~85% of the human proteome http://bhapp.c2b2.columbia.edu/PrePPI (accessed on 9 March 2021)
STRING v11 Experimental & predicted Direct (physical) and indirect (functional) interactions 5090 different organisms >2000 million unique interactions among 24.6 million proteins https://string-db.org/ (accessed on 9 March 2021)