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. 2021 Apr 24;22(9):4460. doi: 10.3390/ijms22094460

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolic symbiosis between GBM and MDSCs and therapeutic potential of T cell metabolic targeting. The figure shows as tumor cells and MDSCs, in a hypermetabolic state, interact to promote an immunosuppressive environment, and some mechanisms of modulation to improve the metabolic performance of T cells. Gln: Glutamine; Arg: Arginine; Trp: Tryptophan; TME: Tumor microenvironment; FA: Fatty acids; TIL: Tumor infiltrating lymphocytes; CAR: Chimeric antigen receptor. Figure adapted from images created with BioRender.com.