Table 1.

Summary of the molecules known to be involved in lymphatic trafficking of leukocytes.

	Homeostasis	Additional Molecules Involved under Inflammatory Conditions
Migration into and through afferent lymphatics	CCL21:CCR7 [24,61,62,63,64,65,66] DCs and T-cells S1P:S1P1 [43,83,84,85] T-cells Semaphorin 3A:Plexin A1 + neuropilin-1 [81] DCs MR:L-selectin [86] T-cells MR:CD44 [87,88] T-cells CLEVER-1 [89,90] T-cells	LYVE-1:HA:CD44 [91,92,93,94,95] DCs VCAM-1:VLA4 [96,97,98,99] DCs and neutrophils ICAM-1:LFA-1 [96,97,98,99,100,101,102,103] DCs, T-cells and neutrophils ALCAM [104,105] DCs L1CAM [106] DCs CD99 [99,107] DCs and neutrophils CD31 [107] DCs CXCL12:CXCR4 [107,108,109,110,111,112,113] DCs CD69 [114] T-cells E-selectin [99] Neutrophils CXCL8 [99] Neutrophils CX3CL1:CX3CR1 [115,116] DCs ACKR2, scavenging CCL2 and CCL5 [117,118,119,120] Antigen-presenting cells and T-cells CCL21:CCR7 [121] Neutrophils (as well as DCs and T-cells) ACKR4, scavenging CCL19 [122] Antigen-presenting cells CCL2:CCR2 [123] DCs and Langerhans cells ROCK [124] DCs
Entry to lymph node via afferent lymphatics and migration within sinuses	CCL21 and CCL19, via CCR7 [24,25,28,65,125] DCs and T-cells MR:CD44 [88] T-cells β1, β2, β7 and/or αv integrins [126] T-cells CCL1:CCR8 [127] DCs PLVAP [128] T-cells ACKR4 and CCR7 ligands [129] DCs	CD209 [130] Neutrophils