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. 2021 Apr 25;22(9):4478. doi: 10.3390/ijms22094478

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mechanistic profile of xanthohumol on various cancers. Abbreviations: APA, alternative polyadenylation; Bcl-2, B-cell lymphoma 2; c-PARP, cleaved poly (ADP-ribose) polymerase; ERK1/2, extracellular signal-regulated protein kinase; FAK, focal adhesion kinase; HES-1, split homolog 1; Hs578T, aneuploid mammary epithelium; IKK, IκB kinase; MDR1, multidrug resistance mutation 1; MRP1; multidrug resistance protein 1, MRP2, multidrug resistance protein 2, MRP3, multidrug resistance protein 3; Mcl-1, myeloid leukemia cell differentiation protein 1; NF-κB, nuclear factor-κB.