Table 2.

Overview of unadjusted and adjusted hazard ratios for key clinico-pathological parameters.

Overall Survival (Combined Cohorts, All Ages)
Analysis	Univariate				Multivariate
Parameter	Hazard Ratio	Lower 95%	Upper 95%	p-value	Hazard Ratio	Lower 95%	Upper 95%	p-value
Age	1.01	0.99	1.03	0.19	1.02	0.99	1.04	0.15
T class	1.86	1.41	2.44	<0.01	1.80	1.31	2.45	<0.01
N class	1.38	1.15	1.64	<0.01	1.24	0.99	1.2	0.05
PRKCA	3.62	1.18	11.45	0.02	3.57	1.53	8.56	<0.01
Smoking	1.54	0.75	4.45	0.29	1.04	0.95	1.14	0.46
Sex	1.08	0.89	1.24	0.45	1.07	0.91	1.15	0.48
Disease-Free Survival (Combined Cohorts, All Ages)
Analysis	Univariate				Multivariate
Parameter	Hazard Ratio	Lower 95%	Upper 95%	p-value	Hazard Ratio	Lower 95%	Upper 95%	p-value
Age	0.98	0.95	1.01	0.58	0.99	0.95	1.02	0.62
T class	0.72	0.34	1.49	0.26	0.86	0.40	1.83	0.70
N class	0.58	0.23	1.39	0.22	0.61	0.23	1.58	0.31
PRKCA	2.82	0.78	10.10	0.11	1.68	0.25	13.23	0.55
Smoking	0.98	0.68	5.03	0.55	0.97	0.88	4.66	0.58
Sex	1.24	0.66	3.32	0.69	1.13	0.76	3.02	0.64