Table 1.
Confirmed genetic variants associated with bladder cancer risk in European.
| Gene (Protein Product) | Polymorphism | Chromosome Location | Position | Nucleotide Change | SNP Function | Risk Allele (Frequency) | Allelic OR (95%CI) | p-Value | Ref. |
|---|---|---|---|---|---|---|---|---|---|
| AL050403.2 | rs62185668 | 20p12.2 | chr20:10981287 | C/A | intron variant | 0.22012 | 1.19 (1.13–1.26) | 2 × 10−11 | [46] |
| PSCA, JRK | rs2294008 | 8q24.3 | chr8:142680513 | C/T | 5′ UTR variant | 0.451005 | 1.15 (1.10–1.20) | 2 × 10−10 | [47,48] |
| TP63, P3H2 | rs710521 | 3q28 | chr3:189928144 | T/C | intergenic variant | 0.257688 | 1.19 (1.12–1.27) | 6 × 10−8 | [49] |
| CASC11, MYC | rs9642880 | 8q24.21 | chr8:127705823 | G/A G/T |
intron variant | 0.000000 0.455939 |
1.21 (1.15–1.28) | 7 × 10−12 | [48] |
| AC023421.2, SLC14A1 | rs7238033 | 18q12.3 | chr18:45737001 | T/C | intron variant | 0.566372 | 1.2 (1.13–1.28) | 9 × 10−9 | [50] |
| TACC3 | rs798766 | 4p16.3 | chr4:1732512 | T/C | intron variant | 0.795826 | 1.24 (1.17–1.32) | 1 × 10−11 | [36,51] |
| PSD3, NAT2 | rs1495741 | 8p22 | chr8:18415371 | G/A | regulatory region variant | 0.756073 | 1.14 (1.09–1.18) | 2 × 10−10 | [52,53] |
| UGT1A8, UGT1A10 | rs11892031 | 2q37.1 | chr2:233656637 | A/C A/T |
intron variant | 0.078850, 0.000000 | 1.19 (1.12–1.27) | 1 × 10−7 | [39,54] |
| CCNE1, AC008798.3 | rs8102137 | 19q12 | chr19:29805946 | T/C | regulatory region variant | 0.306569 | 1.13 (1.09–1.17) | 2 × 10−11 | [39,55] |
| APOBEC3A, AL022318.1 | rs1014971 | 22q13.1 | chr22:38936618 | C/T | regulatory region variant | 0.628195 | 1.18 (1.10–1.18) | 8 × 10−12 | [39,53] |
| CLPTM1L | rs401681 | 5p15.33 | chr5:1321972 | G/A | intron variant | 0.433217 | 1.12 (1.08–1.16) | 4 × 10−11 | [53,56] |
| AC023421.2, SLC14A1 | rs17674580 | 18q12.3 | chr18:45729946 | C/A C/T |
5′ UTRvariant | 0.000000, 0.332221 | 1.17 (1.11–1.22) | 8 × 10−11 | [56,57] |
| LINC02871 | rs6104690 | 20p12.2 | chr20:11007451 | G/A G/T |
intron variant | 0.553042, 0.000000 | 1.12 (1.08–1.18) | 7 × 10−7 | [53] |
| LSP1, TNNI2 | rs907611 | 11p15.5 | Chr11:1852842 | G/A | regulatory region variant | 0.304845 | 1.15 (1.09–1.21) | 4 × 10−8 | [53] |
| MYNN | rs10936599 | 3q26.2 | chr3:169774313 | C/T | synonymous variant | 0.245632 | 1.18 (1.11–1.23) | 5 × 10−9 | [52,53] |
| AL513188.1, CDKAL1 | rs4510656 | 6p22.3 | chr6:20766466 | C/A | intron variant | 0.38803 | 1.12 (1.08–1.18) | 7 × 10−7 | [53] |
| PAG1 | rs5003154 | 8q21.13 | chr8:81074718 | T/C T/G |
intron variant | 0.51809, 0.00000 | 1.11 (1.06–1.16) | 1 × 10−6 | [53] |
| MCF2L | rs4907479 | 13q34 | chr13:113004794 | G/A G/C |
intron variant | 0.23256, 0.00000 | 1.13 (1.07–1.18) | 3 × 10−6 | [53] |