| AKT1 | serine-threonine protein kinase |
| Akt | protein kinase B |
| ALL | acute lymphoblastic leukemia |
| AML | acute myeloid leukemia |
| B-ALL | B-cell acute lymphoblastic leukemia |
| BCL-2 | B-cell lymphoma 2 |
| BCL-XL | B-cell lymphoma-extra large |
| BCP-ALL | B-cell precursor acute lymphoblastic leukemia |
| CNS | central nervous system |
| COG | The Children’s Oncology Group |
| CRT | cranial radiotherapy |
| CR2 | second complete remission |
| DFS | disease-free survival |
| DLBCL | diffuse large B-cell lymphoma |
| EGIL | The European Group for the Immunologic Classification |
| EFS | event-free survival |
| ETP-ALL | early T-cell precursor ALL |
| FBXW7 | F-Box And WD Repeat Domain Containing 7 |
| FCM | flow cytometry |
| FDA | Food and Drug Administration |
| GSI | γ-secretase inhibitors |
| HR | high risk |
| HSCT | hematopoietic stem-cell transplantation |
| IL7R | interleukin-7 receptor |
| JAK 1 | janus kinase 1 |
| LBL | acute lymphoblastic lymphoma |
| MAPK | mitogen-activated protein kinases |
| MRD | minimal residual disease |
| mTOR | mechanistic target of rapamycin |
| MTX | methotrexate |
| OS | overall survival |
| PCR | polymerase chain reaction |
| PDX | patient-derived xenografts |
| PIK3 | phosphoinositide 3-kinase |
| SERCA | sarco/endoplasmic reticulum Ca2+-ATPase |
| SR | standard risk |
| STAT | signal transducer and activator of transcription |
| T-ALL | T-cell acute lymphoblastic leukemia |
| TLX1/3 | T-cell leukemia homeobox protein ⅓ |
| TP | time point |
| WBC | white blood cell |
| T-ALL | T-cell acute lymphoblastic leukemiatime point |
| TLX1/3 | T-cell leukemia homeobox protein ⅓ |
| TP | time point |
| WBC | white blood cell |