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. 2021 Apr 26;22(9):4502. doi: 10.3390/ijms22094502
AKT1 serine-threonine protein kinase
Akt protein kinase B
ALL acute lymphoblastic leukemia
AML acute myeloid leukemia
B-ALL B-cell acute lymphoblastic leukemia
BCL-2 B-cell lymphoma 2
BCL-XL B-cell lymphoma-extra large
BCP-ALL B-cell precursor acute lymphoblastic leukemia
CNS central nervous system
COG The Children’s Oncology Group
CRT cranial radiotherapy
CR2 second complete remission
DFS disease-free survival
DLBCL diffuse large B-cell lymphoma
EGIL The European Group for the Immunologic Classification
EFS event-free survival
ETP-ALL early T-cell precursor ALL
FBXW7 F-Box And WD Repeat Domain Containing 7
FCM flow cytometry
FDA Food and Drug Administration
GSI γ-secretase inhibitors
HR high risk
HSCT hematopoietic stem-cell transplantation
IL7R interleukin-7 receptor
JAK 1 janus kinase 1
LBL acute lymphoblastic lymphoma
MAPK mitogen-activated protein kinases
MRD minimal residual disease
mTOR mechanistic target of rapamycin
MTX methotrexate
OS overall survival
PCR polymerase chain reaction
PDX patient-derived xenografts
PIK3 phosphoinositide 3-kinase
SERCA sarco/endoplasmic reticulum Ca2+-ATPase
SR standard risk
STAT signal transducer and activator of transcription
T-ALL T-cell acute lymphoblastic leukemia
TLX1/3 T-cell leukemia homeobox protein ⅓
TP time point
WBC white blood cell
T-ALL T-cell acute lymphoblastic leukemiatime point
TLX1/3 T-cell leukemia homeobox protein ⅓
TP time point
WBC white blood cell