Table 2.
The shortlisted 64 host proteins with their degree in host-host PPI , disease count (out of 204), disease type count (out of 3), and pathway count (out of 31). Some of the proteins that are known to be targeted by other viruses were also highlighted.
| Gene/Protein | Degree in PPI network | Pathway count | Disease category | Disease count | Known target virus |
|---|---|---|---|---|---|
| ADAM17 | 10 | 2 | Immune | 1 | |
| ALDOA | 26 | 1 | Cardiovascular | 1 | |
| AP3B1 | 17 | 1 | Respiratory | 2 | |
| AREG | 20 | 2 | Respiratory, Cardiovascular, Immune | 10 | |
| ATM | 29 | 6 | Cardiovascular, Immune | 8 | |
| ATP2A2 | 10 | 1 | Cardiovascular | 11 | |
| ATP6 | 19 | 5 | Cardiovascular | 1 | Human SARS coronavirus, Bovine papillomavirus type 1, Human papillomavirus type 16 |
| ATR | 17 | 5 | Respiratory | 2 | Human adenovirus 5 |
| B2M | 25 | 4 | Cardiovascular, Immune | 4 | Hepatitis C virus genotype 1b (isolate Con1) |
| CANX | 31 | 2 | Cardiovascular | 1 | |
| CAPZB | 34 | 1 | Cardiovascular | 1 | |
| CAV1 | 22 | 2 | Respiratory, Cardiovascular, Immune | 17 | Poliovirus type 1 (strain Sabin) |
| CD44 | 19 | 1 | Immune | 1 | |
| COX2 | 9 | 3 | Cardiovascular | 1 | |
| CRKL | 11 | 5 | Cardiovascular | 4 | |
| DDX58 | 10 | 6 | Respiratory, Cardiovascular | 2 | |
| ENO1 | 13 | 1 | Cardiovascular, Immune | 2 | |
| EPHA2 | 9 | 2 | Cardiovascular | 5 | |
| FASN | 9 | 1 | Cardiovascular | 10 | |
| GAPDH | 23 | 2 | Cardiovascular | 1 | Hepatitis C virus genotype 1b (isolate Con1), Epstein-Barr virus (strain GD1) |
| GLA | 16 | 1 | Cardiovascular | 5 | |
| GNAQ | 14 | 5 | Cardiovascular | 1 | |
| GUSB | 16 | 1 | Immune | 1 | |
| HDAC2 | 12 | 5 | Respiratory | 2 | Human herpesvirus 1 (strain 17), Human papillomavirus type 16, Human papillomavirus type 31 |
| HLA-A | 15 | 8 | Immune | 5 | Epstein-Barr virus (strain GD1), Human papillomavirus type 16 |
| HLA-C | 14 | 8 | Immune | 7 | |
| HMGCR | 11 | 1 | Immune | 4 | |
| HSPA1A | 30 | 5 | Cardiovascular | 1 | Epstein-Barr virus (strain GD1) |
| HSPA5 | 46 | 1 | Respiratory, Cardiovascular | 3 | Epstein-Barr virus (strain GD1) |
| IFIH1 | 10 | 3 | Respiratory, Cardiovascular, Immune | 10 | Sendai virus (strain Fushimi) |
| IGF2R | 31 | 2 | Respiratory | 1 | |
| ITCH | 46 | 1 | Immune | 1 | Epstein-Barr virus (strain B95-8) |
| ITGA6 | 10 | 3 | Immune | 1 | |
| ITGB1 | 29 | 5 | Cardiovascular | 10 | Hepatitis C virus genotype 1b (isolate Con1) |
| JAK2 | 22 | 2 | Cardiovascular | 6 | |
| LDHA | 14 | 1 | Cardiovascular | 4 | |
| LDLR | 20 | 2 | Cardiovascular | 4 | |
| MET | 18 | 4 | Respiratory | 1 | |
| NDUFS2 | 20 | 3 | Cardiovascular | 3 | |
| NF1 | 16 | 2 | Cardiovascular | 3 | |
| NOTCH1 | 23 | 3 | Cardiovascular | 4 | Hepatitis C virus genotype 1b (isolate Con1) |
| NOTCH2 | 11 | 2 | Cardiovascular | 1 | |
| NOTCH3 | 15 | 3 | Cardiovascular | 2 | |
| PARP1 | 14 | 1 | Respiratory, Cardiovascular, Immune | 17 | Human herpesvirus 1 (strain 17) |
| PCNA | 25 | 3 | Immune | 1 | Human herpesvirus 1 (strain 17) |
| PDIA3 | 14 | 3 | Cardiovascular | 1 | |
| PLAU | 24 | 1 | Respiratory, Cardiovascular, Immune | 59 | |
| PPP1CB | 14 | 4 | Cardiovascular | 2 | |
| PRKDC | 15 | 1 | Respiratory, Immune | 3 | Human herpesvirus 1 (strain 17) |
| PSMC5 | 34 | 1 | Immune | 7 | Human adenovirus 5, Human adenovirus 12, Simian virus 40 |
| PSMD6 | 24 | 1 | Immune | 2 | |
| PTPN11 | 22 | 1 | Cardiovascular | 6 | |
| RAB5A | 40 | 3 | Cardiovascular | 1 | |
| RAB7A | 41 | 2 | Cardiovascular | 1 | |
| RAB8A | 40 | 3 | Immune | 1 | |
| RBX1 | 58 | 4 | Immune | 5 | |
| SERPINE1 | 16 | 4 | Cardiovascular | 8 | |
| SLC9A1 | 12 | 2 | Cardiovascular | 7 | |
| SORT1 | 14 | 1 | Cardiovascular | 3 | |
| STAT6 | 11 | 1 | Respiratory, Immune | 4 | |
| TGFB1 | 29 | 7 | Respiratory, Cardiovascular, Immune | 29 | Hepatitis C virus genotype 1b (isolate Con1) |
| TGFBR1 | 17 | 9 | Respiratory, Cardiovascular | 6 | |
| TGFBR2 | 16 | 8 | Respiratory, Cardiovascular | 13 | |
| XPO1 | 25 | 2 | Cardiovascular | 2 |