Table 1.
Summary of the clinical and microbiological characteristics of the 13 study patients (seven immunocompromised and six immunocompetent).
| Age (years) Sex |
Diagnosis and medications | Clinical course | Days post symptom onset | PCR result |
Ct value |
Viral culture | |
|---|---|---|---|---|---|---|---|
| Immunocompromised patients | |||||||
| 1 | 34 Female |
Cardiac transplant in 2014 on FK, MMF and prednisolone, epilepsy | Severe pneumonia on high-flow nasal cannula | D3 D26 |
Positive Positive |
NA 22.87 |
NA Negative |
| 2 | 71 Male |
Renal transplant in 2014 on FK, MMF and prednisolone, DM, HTN, and CAD | Severe pneumonia on high-flow nasal cannula | D3 D17 |
Positive Positive |
11.58 23.12 |
NA Negative |
| 3 | 75 Male |
Renal transplant in 2014 on FK, MMF and prednisolone, HTN, BPH | Pneumonia on low-flow nasal cannula | D6 D19 |
Positive Positive |
8.82 13.88 |
NA Negative |
| 4 | 46 Female |
Lymphoma on rituximab | Pneumonia on low-flow nasal cannula | D1 D16 |
Positive Positive |
15.83 21.07 |
NA Positive |
| 5 | 26 Male |
Renal transplant in 2018 on FK, MMF and prednisolone, DM | Pneumonia, not requiring oxygen | D4 D12 |
Positive Positive |
10.38 27.57 |
NA Negative |
| 6 | 38 Female |
Renal transplant in 2014 on FK, AZA and prednisolone, APS, and hypothyroidism | Upper respiratory tract infection | D1 D9 |
Positive Positive |
2.8 14.84 |
NA Negative |
| 7 | 69 Male |
DM, HTN, IHD, CLD, hepatocellular cancer on sorafenib | Upper respiratory tract infection |
D1 D12 |
Positive Positive |
12.86 21.01 |
NA Negative |
| Non-immunocompromised patients | |||||||
| 8 | 60 Female |
DM, HTN, hypopituitarism | Severe pneumonia admitted to ICU, intubated and ventilated | D5 D23 |
Positive Positive |
5 17.5 |
NA Negative |
| 9 | 30 Male |
Von Willebrand disease | Severe pneumonia on high-flow nasal cannula | D8 D11 |
Positive Positive |
9.54 17.53 |
NA Negative |
| 10 | 74 Male |
DM, HTN, CAD | Severe pneumonia on high-flow nasal cannula | D1 D24 |
Positive Positive |
20.01 27.50 |
NA Negative |
| 11 | 54 Female |
DM, HTN | Severe pneumonia on high-flow nasal cannula | D3 D13 |
Positive Positive |
6.77 19.38 |
NA Negative |
| 12 | 66 Female |
Asthma, HTN | Pneumonia, not requiring oxygen | D4 D7 |
Positive Positive |
6 15.34 |
NA Positive |
| 13 | 48 Male |
Hypothyroidism | Pneumonia, not requiring oxygen | D3 D11 |
Positive Positive |
3.33 12.90 |
NA Positive |
APS, anti-phospholipid syndrome; AZA, azathioprine; BPH, benign prostatic hyperplasia; CAD, coronary artery disease; CLD, chronic liver disease; DM, diabetes mellitus; FK, tacrolimus; HTN, hypertension; ICU, intensive care unit; IHD, ischemic heart disease; MMF, mycophenolate mofetil; NA, sample not available for testing. All recruited cases survived until the end of the study.