FIGURE 9.

Hypothetical scheme demonstrating possible consequences in the hypoxic heart. Possible effects of delayed increase of VEGF isoforms and abnormal interaction of the VEGF–KKS in 5 weeks of IH. Decreased ACE activity would increase the local concentration of BK, which in turn stimulates VEGF and interactions with B2R and VEGFR‐2. Furthermore, reduction of B1R downregulates CPM expression and activity in endothelial cells. Therefore, as demonstrated in the present study, the abnormal regulation of B2R/B1R‐VEGF‐R2 may contribute to impaired angiogenesis. Illustration created with BioRender.com