TABLE 4.
Quantification of endothelial progenitor cells and mature endothelial cells in intermittent hypoxia
| Normoxia | IH−1 | IH−2 | IH−3 | IH−4 | IH−5 | |
|---|---|---|---|---|---|---|
| Bone Marrow | ||||||
| %EPC | 0.017 ± 0.001 | 0.005 ± 0.001 | 0.0140 ± 0.003 | 0.0410 ± 0.007*# | 0.0156 ± 0.002 | 0.0216 ± 0.008 |
| % of Mature endothelial cells | 1.25 ± 0.19 | 0.73 ± 0.12 | 1.55 ± 0.12 | 2.74 ± 0.54*# | 1.21 ± 0.29 | 1.57 ± 0.58 |
| Peripheral Blood | ||||||
| %EPC | 0.36 ± 0.10 | 0.91 ± 0.32 | 0.97 ± 0.60 | 0.70 ± 0.18 | 0.24 ± 0.08 | 0.77 ± 0.46 |
| % of Mature endothelial cells | 0.88 ± 0.30 | 1.97 ± 0.68 | 1.78 ± 0.86 | 0.98 ± 0.29 | 0.86 ± 0.28 | 1.11 ± 0.43 |
| Heart | ||||||
| %EPC | 0.004 ± 0.002 | 0.007 ± 0.002 | 0.007 ± 0.003 | 0.020 ± 0.004*# | 0.015 ± 0.002 | 0.003 ± 0.001 |
| % of Mature endothelial cells | 0.030 ± 0.010 | 0.008 ± 0.007 | 0.008 ± 0.002 | 0.022 ± 0.007 | 0.017 ± 0.007 | 0.016 ± 0.005 |
In the bone marrow, % EPCs and % mature endothelial cells were *different from normoxia (p = 0.01), and #from IH‐1 (p = 0.001). In the heart, % EPCs were *different from normoxia (p = 0.01), and #from IH‐1 (p = 0.001). N = 5–6/group. Results are expressed as mean ± SEM.