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Left panel schematically illustrates release of a hydrophobic low-molar-mass compound from a lipophilic depot. Right panel demonstrates the situation when the hydrophilic compound is released from the hydrophilic reservoir. s. c. stratum corneum = thickness 10–15 μm e. epidermis = 150 μm d. dermis = 1–2 mm h. hypodermis/subcutis.
