Table 2.
Group | Active/Medical Principle, Drug | Formal Charge | Water Solubility | References | Note |
---|---|---|---|---|---|
Mitochondrially targeted antioxidants | MitoQ | + | ✓ | [56] | Scavenger of O2●− anion radicals [57,58]. |
SkQ a | + | ✓ | Scavenger of O2●− anion radicals [59]. | ||
Antioxidants | Edaravone | ✓ | [60,61] | Efficient free-radical scavenging properties [14]. | |
Glutathione | + | ✓ | [62,63] | Endogenous antioxidant, H atom and electron donor [21]. | |
Phosphatidylcholine dihydroquercetin | + | (✓) | [64] | Electron donor. | |
Resveratrol | (✓) | [65] | Endogenous antioxidant, H atom and electron donor. | ||
Varia | - | [66,67,68,69,70,71,72] | Wound dressing preparations. | ||
Captopril | ✓ | [73] | H atom donor. | ||
Thiocolchicoside | ✓ | [74] | Muscle relaxant with antiinflammatory and analgesic effects. | ||
Tiopronin | ✓ | [73] | H atom donor. |
a SkQ, analogously as MitoQ, is a proper mitochondrially targeted antioxidant for transdermal application.