Table 2.
Hepatic parameters of lipid metabolism, transport, oxidative and dicarbonyl stress in ovariectomized (W–OVX) rats compared to sham-operated control rats (W–sham).
| W–Sham | W–OVX | p˂ | |
|---|---|---|---|
| Triglycerides in the liver (μmol/g) | 5.44 ± 0.85 | 12.76 ± 1.10 | 0.001 |
| Cholesterol in the liver (μmol/g) | 8.98 ± 0.38 | 7.87 ± 0.64 | n.s. |
| TBARS in the liver (μmol/mg prot) | 1.54 ± 0.16 | 2.07 ± 0.15 | 0.05 |
| Triglycerides in muscles (μmol/g) | 3.79 ± 0.87 | 6.40 ± 0.55 | 0.05 |
| Hepatic SOD (μmol/g) | 0.130 ± 0.012 | 0.110 ± 0.004 | n.s. |
| Hepatic GPx (mmol/L) | 352 ± 17 | 237 ± 9 | 0.01 |
| Hepatic GR (μmol/L) | 116 ± 8 | 108 ± 8 | n.s. |
| GSH in the liver (μmol/g protein) | 63.32 ± 2.50 | 54.64 ± 6.64 | n.s. |
| GSSG in the liver (μmol/g protein) | 2.32 ± 1.43 | 3.71 ± 0.16 | 0.05 |
| GSH/GSSG | 28.36 ± 1.43 | 15.35 ± 1.29 | 0.01 |
| ALT (μkat/L) | 1.16 ± 0.04 | 1.22 ± 0.15 | n.s. |
| AST (μkat/L) | 2.74 ± 0.35 | 3.86 ± 0.47 | 0.05 |
| GGT (μkat/L) | 0.015 ± 0.002 | 0.025 ± 0.003 | 0.05 |
Data are mean ± SEM; n = 8 for each group.