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. 2021 Apr 26;22(9):4517. doi: 10.3390/ijms22094517

Figure 4.

Figure 4

Experimental protocol. Con = Control; Lev = Levosimendan, KHB = Krebs-Henseleit-Buffer; Vehicle = Krebs-Henseleit Buffer (KHB); CsA = Cyclosporine A (mPTP inhibitor). Green bar: Hearts were perfused with a total of 22 mmol/L glucose concentration by combining 11 mmol/L glucose solution with KHB (containing 11 mmol/L glucose). Control (Con): Hearts were perfused with Krebs-Henseleit-Buffer as vehicle for 10 min. Levosimendan 0.3 µM (Lev0.3): Hearts were perfused with 0.3 μM Lev for 10 min. Cyclosporine A (CsA): Hearts were perfused with 0.2 μM CsA for 10 min. Levosimendan 0.3 μM + Cyclosporine A (Lev0.3+CsA): Hearts were perfused with 0.3 μM Lev and 0.2 μM CsA for 10 min.