Table 3.
Baseline | Reperfusion | ||||
---|---|---|---|---|---|
30 | 45 | 60 | |||
Heart Rate (bpm) | |||||
HG | Con | 311 ± 54 | 205 ± 42 * | 220 ± 69 | 192 ± 16 * |
Lev0.3 | 297 ± 30 | 245 ± 87 | 259 ± 45 | 216 ± 52 | |
CsA | 292 ± 23 | 215 ± 63 | 214 ± 67 | 229 ± 47 | |
Lev0.3 + CsA | 306 ± 29 | 297 ± 43 | 267 ± 20 | 265 ± 23 | |
Left Ventricular Developed Pressure (mmHg) | |||||
HG | Con | 117 ± 19 | 20 ± 16 * | 28 ± 16 * | 28 ± 11 * |
Lev0.3 | 106 ± 14 | 15 ± 13 * | 20 ± 19 * | 25 ± 16 * | |
CsA | 123 ± 26 | 35 ± 8 * | 37 ± 13 * | 35 ± 10 * | |
Lev0.3 + CsA | 112 ± 21 | 23 ± 18 * | 24 ± 13 * | 24 ± 12 * | |
Coronary flow (mL/min) | |||||
HG | Con | 15 ± 3 | 7 ± 3 * | 6 ± 1 * | 6 ± 2 * |
Lev0.3 | 13 ± 2 | 6 ± 1 * | 6 ± 1 * | 5 ± 1 * | |
CsA | 15 ± 2 | 5 ± 1 * | 6 ± 1 * | 6 ± 1 * | |
Lev0.3 + CsA | 14 ± 2 | 7 ± 2 * | 7 ± 2 * | 6 ± 1 * |
Data are mean ± SD. HG = Hyperglycemia; Con = Control; Lev = Levosimendan; CsA = Cyclosporine A (mPTP inhibitor); * p < 0.05 vs. Baseline.