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. 2021 Apr 27;13(9):2100. doi: 10.3390/cancers13092100

Figure 1.

Figure 1

BLBP expression in a sub-population of cells is associated with poor prognosis in ependymoma patients. (a) In normal foetal brain tissue, 70–80% of cells expressed BLBP. (b) A BLBP-positive paediatric ependymoma demonstrating typical staining of a sub-population of cells. Scale bars represent 50µm. (c,d) In the chemotherapy-led CNS9204 trial, BLBP-positive patients had a significantly reduced event-free survival (c) (5-year EFS 27% versus 58%, p = 0.028) and overall survival (d) (5-year OS 44% versus 82%, p = 0.01), respectively. (e,f) In the radiotherapy-led CNS9904, BLBP expression did not correlate with reduced event-free survival (e) (5-year EFS 33% versus 61%, p = 0.106); however, it was significantly associated with reduced overall survival (f) (5-year OS 38% versus 84%, p = 0.002).