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. 2021 Apr 27;22(9):4548. doi: 10.3390/ijms22094548

Figure 1.

Figure 1

Liquid biopsy approaches utilized in central nervous sytem tumor diagnosis or monitoring. Upper left panel: CNS tumor of unknown diagnosis with local brain inflammation. Middle panel: Tumor analyte enters biofluid, with circulating tumor cell entering bloodstream and a representative example process is shown. Lower right panel: analytes of interest depicted in the bloodstream as representative biofluid, including circulating tumor cells, circulating tumor DNA (ctDNA), microRNAs (miRNA), proteins, metabolites and exosomes/extracellular vesicles (EVs) (created with BioRender.com, accessed on 14 February 2021).