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Potential mechanisms triggering sepsis-induced abnormalities in skeletal muscles. Circulating pathogens and cytokines interfere with satellite cell function resulting in impaired muscle-regenerative capacity and atrophy pathways. Damaged mitochondria result in the release of factors that further exacerbates the myopathy. DAMP = damage associated molecular pattern, EMVs = Extracellular Membrane Vesicles; miRNA = microRNA; APP = acute phase proteins.
