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. 2021 Apr 27;22(9):4546. doi: 10.3390/ijms22094546

Figure 1.

Figure 1

Key events in the ubiquitylation and deubiquitylation process [1,2,3]. E1: ubiquitin-activating enzyme; E2: ubiquitin-conjugating enzyme; E3: ubiquitin-protein ligase; Ub: ubiquitin. Really interesting new gene (RING) E3 ligases which represent the vast majority of E3 ligases are depicted here as an example.