Skip to main content
. 2021 Apr 27;22(9):4546. doi: 10.3390/ijms22094546

Figure 23.

Figure 23

Cocrystal structure of USP14-IU1-248 and a close-up of the binding site (PDB ID: 6IIN). A ubiquitin molecule is modeled into the complex based on the superposition with a USP14CD-ubiquitin complex (PDB ID: 2AYO). Ubiquitin: magenta; USP14 catalytic domain: gray; IU1-248: cyan sticks. Hydrogen bonds: yellow dotted lines. Key residues involved in binding and the catalytic triad (Cys114-His435-Asp451) are shown as sticks, with Cys114 in orange. The ubiquitin C-terminal peptide RLRGG is omitted for clarity.