Table 1.
Cancer-related pathways regulated by USPs.
| Pathway | USPs Involved | Refs |
|---|---|---|
| DNA damage repair | USP1, USP28 | [35,36] |
| TGF-β | USP2a, USP4, USP9X, USP15, USP26 | [34,37,38,39,40] |
| Wnt/β-catenin | USP4, USP5, USP9X, USP14 | [41,42,43,44,45] |
| p53 | USP2, USP4, USP5, USP7, USP10, USP15, USP24, USP42 | [31,32,33,46,47,48,49,50,51,52,53,54,55] |
| c-Myc | USP2, USP10, USP22, USP28, USP36, USP37 | [56,57,58,59,60,61] |
| Akt | USP4, USP12, USP14, USP22, USP46 | [62,63,64,65,66,67] |
| JAKs-STATs | USP7 | [68] |
| NF-κB | USP4, USP11, USP14, USP15, USP18, USP19, USP20, USP35, USP24, USP48 | [69,70,71,72,73,74,75,76,77,78,79,80,81,82] |
| GPCR | USP4, USP8, USP14, USP20, USP30 | [83,84,85,86] |