Table 2.
List of reported USP inhibitors.
| Target | Compound ID | PDB | Refs |
|---|---|---|---|
| USP inhibitors in clinical trials | |||
| USP14/UCHL5 | b-AP15 | None | [103] |
| VLX1570 | None | [109] | |
| USP inhibitors of reported new chemical entities | |||
| USP1 | Pimozide | None | [113] |
| GW7647 | None | ||
| Trifluoperazine | None | ||
| Rottlerin | None | ||
| C527 | None | [114] | |
| SJB2-043 | None | ||
| SJB3-091A | None | ||
| ML323 | None | [115,116] | |
| USP2 | Q29 | None | [117] |
| ML364 | None | [118] | |
| LCAHA | None | [119] | |
| STD1T | None | [120] | |
| 6TG | 5XU8 | [121] | |
| USP2/4/5/7/8/15/20/28/47/UCHL1/UCHL3/UCHL5 | PR619 | None | [122,123] |
| USP2/5/8/UCHL1/UCHL3 | AM416 | None | [124] |
| RA9 | None | ||
| RA14 | None | ||
| USP2/7 | NSC632839 | None | [98] |
| Compound 14 | None | [125] | |
| USP4/5 | Vialinin A | None | [126] |
| USP5/7/8/13/14/15/22 | Curcusone D | None | [127] |
| USP5/9X/14/24/UCHL5 | WP1130 (Degrasny) | None | [128,129,130,131] |
| EOAI3402143 (G9) | None | [132] | |
| USP7 | HBX-41108 | None | [133] |
| HBX-19818 | None | [134] | |
| HBX-28258 | None | ||
| Spongiacidin A | None | [135] | |
| GEN-6640 | 5UQV | [136] | |
| GEN-6776 | 5UQX | ||
| XL188 | 5V6S | [137] | |
| ALM2 | 5N9R | [138] | |
| ALM45 | 6F5H | [139] | |
| FT671 | 5NGE | [140,141] | |
| FT827 | 5NGF | ||
| Compound 2 | 5WHC | [142] | |
| Compound 28 | None | ||
| Parthenolide (PTL) | None | [143] | |
| Costunolide | None | ||
| α-santonin | None | ||
| USP7/8 | HY50736 | None | [144] |
| HY50737A | None | ||
| USP7/10 | Compound 3 | None | [145] |
| Compound 9 | None | ||
| USP7/47 | P22077 | None | [122,146,147] |
| P5091 | None | [148,149,150] | |
| P50429 | None | [151] | |
| USP10/13 | Spautin-1 | None | [152] |
| USP11/15 | Mitoxantrone | 6GH9 | [153,154] |
| USP14 | IU1 | 6IIK | [155] |
| IU1-47 | 6IIL | [156,157] | |
| IU1-206 | 6IIM | [157] | |
| IU1-248 | 6IIN | [157] | |
| USP14/UCHL5 | Auranofin | None | [158,159] |
| CuPT | None | [160,161] | |
| PtPT | None | [162] | |
| NiPT | None | [163] | |
| USP25/28 | AZ1 | None | [164] |
| USP30 | MF-094 | None | [165] |
| 15-oxospiramilactone (S3) | None | [166] | |