Figure 2.

Plasma pyrophosphate levels do not correlate with the calcification phenotype in mice. Plasma pyrophosphate levels in Abcc6^−/− mice (C57BL/6J background), and in C3H/H1J mice with a naturally occurring Abcc6 mutation are virtually identical and significantly lower than wild type C57BL/6J mice. However, at 12 months of age, Abcc6^−/− mice present a much more pronounced vibrissae calcification as shown on this μCT scan rendering (right, arrows). Plasma PPi results are shown as means +SEM. p-values were determined by Student’s t-test. ** p < 0.01, **** p < 0.0001. Derived from [111].