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. 2021 Apr 26;18(9):4588. doi: 10.3390/ijerph18094588

Table 1.

Comparison of Liverpool and Waikato Diagnostic and Treatment Approaches for Gestational Diabetes Diagnosis.

Waikato NZSSD 1995 [10] Waikato NZMOH 2014 Liverpool ADIPS 1991 [7,8] Liverpool IADPSG [9,13]
SCREENING APPROACH
Universal GCT Booking HbA1c (<20 weeks)
  • If ≤40 mmol/mol (5.8%), do GCT

  • if 41–49 mmol/mol (5.9–6.6%), do OGTT

  • ≥50 mmol/mol (6.7%), referral to diabetes in pregnancy service

Risk-based screening:
  • Low risk groups: GCT at 26–28 weeks, if ≥7.8 mmol/L then OGTT

  • High risk groups *: OGTT at time of antenatal booking, if normal repeat OGTT at 26–28 weeks

  • Universal OGTT at 24–28 weeks

  • Early OGTT performed at any time for those with 1 high risk factors or 2 moderate risk factors *

RISK FACTORS FOR SCREENING
Risk factors include glycosuria, age > 30 years, obesity, family history of diabetes, past history of GDM or glucose intolerance, previous adverse pregnancy outcome, belonging to an ethnic group with a high risk for GDM (e.g., Indigenous, Polynesian, Middle Eastern and Asian). High risk factors include: previous GDM, elevated BGL, age ≥ 40 years, 1st degree family history (or sister with GDM), BMI > 35 kg/m2, previous macrosomia (>4500 g or >90th centile), polycystic ovarian syndrome, on corticosteroids or antipsychotics.
Moderate risk factors include: Asian, Indian subcontinent, Aboriginal, Torres Strait Islander, Pacific Islander, Maori, Middle Eastern, or non-white African ethnicity. BMI 25–35 kg/m2.
ORAL GLUCOSE TOLERANCE TEST DIAGNOSTIC CUT OFFS
1-h 50 g GCT cut offs:
  • -

    ≥11.1 mmol/- referral to diabetes in pregnancy service

  • -

    7.8–11.0 mmol/L, proceed to OGTT

  • If HbA1c at booking is ≤40 mmol/mol (5.8%)

  • If ≥7.8 mmol/L, proceed to OGTT

OGTT fasting level (mmol/L) ≥5.5 ≥5.5 ≥5.5 ≥5.1
OGTT 1-h level ≥10.0
  • -

    OGTT 2-h level (mmol/L)

≥9.0 ≥9.0 ≥8.0 ≥8.5
TREATMENT TARGETS
  • -

    Fasting BGL (mmol/L)

≤5.5 ≤5.0 ≤5.5 ≤5.3
  • -

    1-h BGL (mmol/L)

≤7.4 N/A ≤7.4
  • -

    2-h BGL (mmol/L)

≤6.5 ≤6.7 ≤7.0 ≤7.0

BGL = blood glucose level, GCT = glucose challenge test, ADIPS = Australian Diabetes in Pregnancy Society, IADPSG = International Association of Diabetes and Pregnancy Study Groups, NZMOH = New Zealand Ministry of Health, NZSSD = New Zealand Society for Study of Diabetes, OGTT: oral glucose tolerance test. * Risk factors described in section “Risk Factors for Screening”