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. 2021 Apr 27;22(9):4591. doi: 10.3390/ijms22094591

Figure 2.

Figure 2

Cellular iron regulation. The intracellular iron pool is regulated by the binding of IRP1 and IRP2 to IRE. IRP1 and IRP2 are RNA binding proteins that interact with IRE to control the translation of proteins involved in iron metabolism. IRPs are either present at the 3′ UTR or the 5′ UTR of the target mRNA. When an IRP binds to a single IRE at the 5′ UTR, mRNA translation is repressed. On the other hand, the binding of IRP to IRE at the 3′ UTR stabilizes the transcript and leads to increased mRNA translation. The illustration was created using BioRender.com, (accessed on 3 April 2021).