Figure 1.

Upregulation of DNA damage pathways in breast cancer. (A) Gene set enrichment network comparing normal versus breast tumoral tissue. All gene sets from the Pathway Interaction Database are included, those overexpressed in the tumoral phenotype, are displayed in shades of red, and those overexpressed in the normal phenotype are displayed in shades of blue; while the size of the circle indicates the number of genes within the gene set. (B) ES Score profile and locations of DNA Damage pathways “ATR pathway”, “Fanconi Anemia pathway”, “BARD1 pathway,” and “ATM pathway” members on the rank ordered list. Positive NES defines tumoral phenotype enrichment. (C) Blue–red diagram of all the genes that composed the DNA Damage pathways showing overexpressed genes in shades red, and downregulated genes in shades of blue.