Figure 2.

Amplification and expression change of DNA damage response genes in different breast cancer subtypes. (A) Bar graph showing fold change expression or (B) the percentage of amplified cases of genes involved in the ATR, Fanconi Anemia, ATM, and BARD1 pathways in each breast cancer subtype (red, basal-like; yellow, HER2⁺; blue, luminal B and green, luminal A). The dot line represents the threshold we mark for each alteration. (C) Dot plot of DNA damage response genes showing fold change expression in X-axes and percentage of amplified cases in Y-axes for each molecular subtype. Those genes that exceed both thresholds are highlighted following the same color criteria than in A.