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. 2021 Apr 27;13(9):2112. doi: 10.3390/cancers13092112

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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High LAG-3 expression on leukemic cells correlates with poor outcome in CLL. (A) Kaplan-Meier survival analysis relative to LAG-3 surface expression and TTT in 61 patients with CLL; (B) In silico analysis of OS in 107 patients with CLL using ShinyGeo online tool (GSE22762); (C) Heatmap representing z-score corresponding to the expression of LAG3 and MHC class II genes and its influence in OS in diverse hematological malignancies analyzed by PRECOG tool (CLL: chronic lymphocytic leukemia; FL: follicular lymphoma; DLBCL: diffuse large B-cell lymphoma; BL: Burkitt leukemia/lymphoma; MM: multiple myeloma; ALL: acute lymphoblastic leukemia; AML: acute myeloid leukemia).