Table 1.

Selected latest bioinformatics tools dedicated to genome mining NPs (2015–2020).

Platform	Description	Web Server URL	Reference
BIG-FAM	Global biosynthetic space of microbial BGC families database	https://bigfam.bioinformatics.nl, accessed on 10 February 2021	Kautsar et al. [35]
MIBiG 2.0	Minimum information on biosynthetic gene clusters (MIBiG) standard respiratory of characterized BGCs	https://mibig.secondarymetabolites.org, accessed on 10 February 2021	Kautsar et al. [36]
antiSMASH 5.0	Automated pipeline to mine secondary metabolite BGCs	https://antismash.secondarymetabolites.org, accessed on 10 February 2021	Blin K et al. [37]
PRISM 4	Automated pipeline to mine secondary metabolite BGCs	http://prism.adapsyn.com, accessed on 10 February 2021	Skinnider et al. [38]
BAGEL 4	Mining of RiPP and bacteriocins BGCs	http://bagel4.molgenrug.nl, accessed on 10 February 2021	Van Heel et al. [39]
BiG-SPACE - CORASON	Biosynthetic gene similarity clustering and prospecting engine	https://bigscape-corason.secondarymetabolites.org, accessed on 10 February 2021	Navarro-Muňoz et al. [40]
ARTS	Mining of BGCs on the basis of the prediction of antimicrobial resistance genes that are part of BGCs	https://arts.ziemertlab.com, accessed on 10 February 2021	Alanjary et al. [41]
CASSIS/SMIPS	Mine for PKS, NRPS, and DMATS anchor genes (SMIPS) in fungal genomes; predict gene clusters around anchor genes on the basis of conserved promoter regions	https://sbi.hki-jena.de/cassis/, accessed on 10 February 2021	Wolf et al. [42]
IMG-ABC	A comprehensive database of secondary metabolite BGCs	https://img.jgi.doe.gov/abc, accessed on 10 February 2021	Hadjithomas et al. [43]
RiPPMinner	Analysis of RiPP precursor peptides to predict structural features	https://www.nii.ac.in/~priyesh/lantipepDB/newpredictions/index.php, accessed on 10 February 2021	Agrawal et al. [44]
RiPP-RODEO	Mining and analysis of RiPPs	https://www.ripprodeo.org/, accessed on 10 February 2021	Tiez et al. [45]