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. 2021 Apr 27;22(9):4587. doi: 10.3390/ijms22094587

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Epigenetic changes of the CYP11B2 promoter region. Binding activities of coactivator complex, such as CREB and NURR1 and corepressor complex MECP2 are regulated by DNA methylation. Methylation of Cpg1 greatly decreased the CREB1 binding to Ad1. DNA methylation at CpG2 reduced the basal binding activities of NR4A1(NGF1B) and NR4A2 (NURR1) with A5. DNA methylation increased the MECP2 binding to CpG1 and CpG2. The closer relationship between other MBD-related corepressors and gene expression should be clarified.