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(A) Schema of CpG dinucleotides within the human CYP11B2 gene promoter. Open circle denotes CpG dinucleotides. (B) Inverse correlation between DNA methylation and CYP11B2 mRNA levels. The CYP11B2 mRNA level was significantly elevated in APA. The CpG methylation ratios of the CYP11B2 promoter was significantly decreased in APA. * p < 0.05 compared to aldosterone-producing adenoma (APA) (n = 9, APA; n = 5, non-APA; n = 4, the adrenal gland; n = 3, the artery).
