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. 2021 May 11;14:1797–1809. doi: 10.2147/IJGM.S293998

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© 2021 Li et al.

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Representative images. (A–E): A 31‐year‐old female patient with HR+/HER2- MBC underwent PET/CT scan (A, maximum intensity projection image). We detected that the first lumbar vertebra lesion had the highest 18F‐FDG uptake in all metastatic lesions (B, CT image; C, PET image, SUVmax were 5.43), whereas the right axillary lymph node lesion had the lowest uptake (D, CT image; E, PET image, minimum FDG uptake across all lesions = 3.58). Therefore, HI of this patient was 1.52, and she had a median PFS of 57.4 months. (F–J): A 30‐year‐old female patient with HR+/HER2- MBC underwent 18F‐FDG PET/CT scan (F, maximum intensity projection image). We detected that the chest wall lesion had the highest 18F‐FDG uptake in all metastatic lesions (G, CT image; H, PET image, SUVmax = 15.71), whereas right axillary lymph node lesion had the lowest uptake (I, CT image; J, PET image, minimum FDG uptake = 3.79); Therefore, HI of this patient was 4.15, and she had a PFS of 5.2 months.

Abbreviations: HR, hormone receptor, HER2, human epidermal growth factor receptor 2; MBC, metastatic breast cancer; PET/CT; positron emission tomography/computed tomography; 18F‐FDG, 18F-ﬂuorodeoxyglucose; SUVmax, maximum standardized uptake value; HI, heterogeneity index, PFS, progression-free survival.