Table 1.
Gene | Phenotype | Reference |
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ADRB2 rs1042713rs1042714 | Starch obesity | V. Large, L. Hellstrom, S. Reynisdottir et al. “Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function,” J Clin Invest, vol. 100, no. 12, pp. 3005–3013. J.A. Martínez, M.S. Corbalán, A. Sánchez-Villegas, L. Forga, A. Marti, and M.A. Martínez-González, “Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta-2 adrenoceptor polymorphism,” J Nutr, vol. 133, no. 8, pp. 2549–2554. |
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ADRB3 rs4994 | Visceral obesity | H. Kim-Motoyama, K. Yasuda, T. Yamaguchi et al., “A mutation of the beta-3 adrenergic receptor is associated with visceral obesity but decreased serum triglyceride,” Diabetologia, vol. 40, no. 4, pp. 469–472. |
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GNB3 rs5443 | Metabolism obesity | K.D. Ko, K.K. Kim, H.S. Suh, and I.C. Hwang, “Associations between the GNB3 C825 T polymorphism and obesity-related metabolic risk factors in Korean obese women,” J Endocrinol Invest, vol. 37, no. 11, pp. 1117–1120. |
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UCP1 rs1800592 | Stubborn obesity | R.A. Busiello, S. Savarese, and A. Lombardi, “Mitochondrial uncoupling proteins and energy metabolism,” Front Physiol, vol. 6, p. 36. M. Dhall, M.M. Chaturvedi, U. Rai, and S. Kapoor, “Sex-dependent effects of the UCP1 -3826 A/G polymorphism on obesity and blood pressure,” Ethn Dis, vol. 22, no. 2, pp. 181–184. |
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FTO rs9939609 | Energy intake | E. Karra, O.G. O'Daly, A.I. Choudhury et al. “A link between FTO, ghrelin, and impaired brain food-cue responsivity,” J Clin Invest, vol. 123, no. 8, pp. 3539–3551. |
BMI | M. Claussnitzer, S.N. Dankel, K.H. Kim et al., “FTO obesity variant circuitry and adipocyte browning in Humans,” N Engl J Med, vol. 373, no. 10, pp. 895–907. |