Table 4.
Logistic regression model of factors associated with regret of focal therapy
| Variable | Direction and unit | Univariable analyses | Multivariable analyses | ||||
|---|---|---|---|---|---|---|---|
| Odds Ratio | 95% CI | p value | Odds Ratio | 95% CI | p value | ||
| Age ≥ 65 years | Yes vs. no | 1.89 | 0.45–9.80 | 0.4047 | |||
| Married | Yes vs. no | 1.00 | 0.12–20.99 | 1.0000 | |||
| Housing situation | Living with partner or shared flat (vs. living alone) | 0.73 | 0.08–15.78 | 0.7941 | |||
| Education | University or college (vs. lower) | 0.58 | 0.13–2.53 | 0.4684 | |||
| Employment | Full-/part time (vs. retired) | 0.40 | 0.02–2.66 | 0.4198 | |||
| Insurance | Private/combined (vs. statutory) | 0.53 | 0.10–2.32 | 0.4125 | |||
| PSA increase | Yes vs. no | 1.44 | 0.32–6.05 | 0.6163 | |||
| Cancer recurrence | Yes vs. no | 6.86 | 1.47–49.89 | 0.0250 | 12.31 | 1.78–159.26 | 0.0225 |
| Recurrent Gleason Score 3 + 3 | Yes vs. no | 1.33 | 0.23–7.97 | 0.7464 | |||
| Recurrent Gleason Score ≥ 3 + 4 | Yes vs. no | 0.75 | 0.13–4.40 | 0.7464 | |||
| Salvage therapy | Yes vs. no | 2.45 | 0.58–10.57 | 0.2165 | |||
| Urinary incontinence | CMI vs. no CMI | 4.43 | 0.99–20.53 | 0.0497 | 5.67 | 0.76–56.97 | 0.1010 |
| Urinary irritative/obstructive symptoms | CMI vs. no CMI | 1.61 | 0.30–7.37 | 0.5514 | |||
| Erectile dysfunction | CMI vs. no CMI | 0.54 | 0.07–2.58 | 0.4780 | |||
| General health rating | Excellent/very good/good (vs. poor/very poor) | 0.26 | 0.05–3.10 | 0.3090 | |||
| Charlson Comorbidity Index | Increasing units | 0.11 | 0.003–2.13 | 0.1783 | |||
| Proportional age discrepancy score | Increasing units | 5.55 | 0.01–5922.09 | 0.5997 | |||
| AARC-10 gains | Increasing units | 1.01 | 0.82–1.27 | 0.8968 | |||
| AARC-10 losses | Increasing units | 0.99 | 0.79–1.22 | 0.8961 | |||
| Health worry | Increasing units | 1.06 | 1.03–1.12 | 0.0034 | 1.07 | 1.03–1.14 | 0.0096 |
| PSA concern | Increasing units | 1.02 | 0.97–1.09 | 0.4521 | |||
| Outlook | Increasing units | 0.99 | 0.96–1.02 | 0.5354 | |||
| Informed decision making | Increasing units | 0.96 | 0.91–1.00 | 0.0987 | |||
Bold values are indicate statistically significant variables
Urinary incontinence, urinary irritative/obstructive symptoms, erectile dysfunction: domains of EPIC-26; General health rating: Item of SF-12; Health worry, PSA concern, Outlook, Informed decision making: domains of Clark’s scale
AARC-10 awareness of age-related change short form, CI confidence interval, CMI clinically meaningful impairment, PSA prostate specific antigen