TABLE 2.
Concordance analysis of p.T790 M mutation status between matched tumor samples and sputum cfDNA samples that are classified by cytological evaluation
| Cytology evaluation | p.T790 M status in sputum cfDNA | ||||||
|---|---|---|---|---|---|---|---|
|
Malignant N = 8 |
Satisfactory but no malignant cells N = 10 |
Unsatisfactory N = 3 |
|||||
| Matched tumor sample | p.T790 M | Positive | Negative | Positive | Negative | Positive | Negative |
| Positive | 4 | 0 | 2 | 1 | 0 | 2 | |
| Negative | 0 | 4 | 0 | 7 | 0 | 1 | |
| Sensitivity % (95% CI) | 66.7% (30.9%, 90.9%) | ||||||
| 100% | 66.7% | 0% | |||||
| (39.6%, 100%) | (12.5%, 98.2%) | (0%, 80.2%) | |||||
| Specificity % (95% CI) | 100% (69.9%, 100%) | ||||||
| 100% | 100% | 100.00% | |||||
| (39.6%, 100%) | (56.1%, 100%) | (5.5%, 100%) | |||||
| PPV % (95% CI) | 100% (51.7%, 100%) | ||||||
| 100% | 100% | / | |||||
| (39.6%, 100%) | (19.8%, 99.1%) | ||||||
| NPV% (95% CI) | 80% (51.4%, 94.7%) | ||||||
| 100% | 87.5% | 33.3% | |||||
| (39.6%, 100%) | (46.7%, 99.3%) | (1.8%, 87.5%) | |||||