Table 1.
Frequencies of co-mutation and concurrent copy number gain variants in the eight actionable gene groups.
| Driver Gene Mutation | n (%) | Presence of Co-Mutations (%) | Presence of CNVs (%) | ||
|---|---|---|---|---|---|
|
KRAS G12C non-G12C |
135 (43.7%) 49 (36.3%) 86 (63.7%) |
104 (77%) 37 (75.5%) 67 (77.9%) |
p value = 0.75 |
51 (37.8%) 20 (40.8%) 31 (36%) |
p value = 0.58 |
|
EGFR del19 + L858R other |
62 (20%) 50 (80.6%) 12 (19.4%) |
52 (83.9%) 41 (82%) 11 (91.7%) |
p value = 0.41 |
36 (58.1%) 31 (62%) 5 (41.7%) |
p value = 0.19 |
|
MET exon14 skipping amplification (CNV ≥ 6) |
29 (9.4%) 6 (20.7%) 23 (79.3%) |
25 (86.2%) 2 (33.3%) 23 (100%) |
p value < 0.001 |
14 (48.3%) 4 (66.7%) 10 (43.5%) |
p value = 0.08 |
|
BRAF V600 non-V600 |
10 (3.2%) 3 (30%) 7 (70%) |
9 (90%) 2 (66.7%) 7 (100%) |
p value = 0.65 |
14 (48.3%) 4 (66.7%) 10 (43.5%) |
p value = 0.08 |
| ALK | 41 (13.3%) | 18 (43.9%) | 5 (12.2%) | ||
| HER2 | 4 (1.3%) | 4 (100%) | 2 (50%) | ||
| RET | 16 (5.2%) | 11 (68.8%) | 3 (18.8%) | ||
| ROS1 | 12 (3.9%) | 7 (58.3%) | 1 (8.3%) | ||
| Total | 309 (100%) | 229 (74.1%) | 114 (36.9%) | ||